Friedrich Wieser, MD, PD - Assistant Professor

Frederich Wieser





Research - Human Uterine Biology Center




Education & Training   


Medical Education: Vienna University School of Medicine, MD, 1993 


Residency: Vienna University School of Medicine, Department of Obstetrics and Gynecology, 1994

Erwin Schroedinger Fellowship: University of California at San Francisco Center for Reproductive Sciences, Department of Gynecology and Obstetrics, 2005

Graduate Education: Vienna University School of Medicine, PD, 2004


Society & Professional Memberships  


•  Society for Gynecologic Investigation
•  Austrian Scientists and Scholars in North America
•  World Endometriosis Society
•  Endometriosis Association
•  American Society for Reproductive Medicine 
•  Society of the Study of Reproduction 
•  Georgia Obstetrical and Gynecological Society, Inc. 
•  Winship Cancer Institute

 
Awards and Honors


•  Frontiers in Stem Cells & Regeneration Course at MBL (no. 1852); Woodshole, MA, 2010
•  Grant from the Emory University Research Committee, Atlanta, GA, 2008, 2007
•  Full Member of the SGI - Society for Gynecologic Investigation, Washington, D.C., 2006
•  Grant from the Oracle Foundation, San Francisco, CA, 2005, 2004
•  Erwin Schrödinger Grant (no. J2288-B13), Vienna, Austria and San Francisco, CA, 2005, 2004, 2003
•  Grant of the Austrian National Bank (no. 9194); Vienna, Austria, 2002, 2001
•  Major grant of the City of Vienna (no. 1815); Vienna, Austria, 2001, 2000

Academic


Emory University School of Medicine 
Department of Gynecology and Obstetrics 
1639 Pierce Drive, Room 4211 WMB
Atlanta, GA 30322 
Phone: 404-727-9965

Research


•  Cellular and molecular biology of reproductive diseases including endometriosis, endometrial cancer, and ovarian cancer

•  Special areas of focus are:
1)  Elucidation of the mechanisms of action of anti-inflammatory agents in endometriosis and ovarian cancer and develop alternative, novel treatments with higher efficacy
2)  Investigation of the role of environmental and genetic factors in the pathogenesis of reproductive disorders with emphasis of nutrition and stress on the inflammatory and etiological pathways

Selected Peer-Review Publications


Wieser F, Wu J, Zhaoju S, Sidell N. Retinoid acid suppresses growth of endometriotic implants in an immunocompetent mouse model of endometriosis. Fertil Steril. 2012.

Boneva RS, Lin JS, Maloney EM, Jin-Mann  L, Jones J, Wieser F, Nater U, Heim CM, Reeves WC. Gynecologic History in Chronic Fatigue Syndrome (CFS): a population-based case-control study. J Women Health 2011 Jan;20:21-8.

Dun E, Taylor RN, Wieser F. Advances in the genetics of endometriosis. Genome Medicine 2010 14:2:75.

Tan X, Sidell N, Mancini A, Huang RP, Taylor RN, Wang S, Horowitz I, Liotta D, Wieser F. Anticancer activity of EF24, a novel curcumin analog, on human malignant ovarian tumor cells. Reproductive Sciences 2010; 17: 931 - 940.

Wieser F, Yu J, Park J, Gaeddert A, Cohen M, Vigne JL, Taylor RN. A botanical extract from Channel Flow inhibits cell proliferation, induces apoptosis, and suppresses RANTES in human endometriotic stromal cells. Biol Reprod 2009: 371-379.

Wieser F, Waite L, Depoix C, Taylor RN. PPAR Action in human placental development and pregnancy and its complications. PPAR Research 2008:527048.

Wieser F, Cohen M, Gaeddert A, Yu J, Burks-Wicks C, Berga SL, Taylor RN. Evolution of medical treatment for endometriosis: Back to the roots? Hum Reprod Update 2007; 13:487-499.

Burcks-Wicks C, Cohen M, Fallbacher J, Taylor RN, Wieser F. A Western primer of Chinese herbal medicine therapy in endometriosis and infertility. Future Drugs 2005;4;447-463.

Hudelist G, Keckstein J, Czerwenka K, Lass H, Walter I, Auer M, Wieser F, Wenzl R, Kubista E, Singer CF. Estrogen receptor beta and matrix metalloproetinase 1 are expressed in uterine endometrium and endometriotic lessions of patients with endometriosis. Fertil Steril 2005;84:1249-56.

Wieser F, Vigne JL, Ryan I, Hornung D, Djalali S, Taylor RN. Sulindac suppresses NF (nuclear factor)-KappaB activation, RANTES gene and protein expression in endometrial stromal cells from women with endometriosis. J Clin Endocrinol Metab. 2005;90;6441-6447.

Wieser F, Vigne J-L, Wenzl R, Huber JC, Taylor R. Effects of phorbol dibutyrate (PDB) on cell proliferation, apoptosis and TNF-alpha expression, in human endometrial adenocarcinoma cells. J Soc Gynecol Invest 2005;370-375.

Wieser F, Dogan S, Bühring HJ, Klingel K, Diedrich K, Taylor RN, Hornung D. Expression and Regulation of CCR1 in Peritoneal Macrophages from Women with and without Endometriosis. Fertil Steril 2005;83:1878-81.

Hudelist G, Lass H, Keckstein J, Walter I, Wieser F, Wenzl R, Mueller R, Czerwenka K, Kubista E, Singer CF. Interleukin 1-alpha and tissue-lytic matrix metalloproteinase-1 are elevated in ectopic endometrium of patients with endometriosis. Hum Reprod 2005;20:1695-1701.

Wieser F, Wenzl R, Taylor RN, Diedrich K, Hornung D. Genetik der Endometriose. Der Gynaekologe 2004 Band 37, Heft 8:676-680.

Gruber CJ, Gruber DM, Gruber IM, Wieser F, Huber JC. Anatomy of the estrogen response element. Trends Endocrinol Metab 2004;15:73-8.

Gruber CJ, Hengstschlager M, Wieser F, Gruber DM, Walch K, Ferlitsch K, Gruber IM, Maar A, Marton E, Bernaschek G, Huber JC. Wien Klin Wochenschr. Absence of microdeletions in the azoospermia-factor region of the Y-chromosome in Viennese men seeking assisted reproduction. 2003; 115:831-834.

Wieser F, Hefler L, Tempfer C, Vlach U, Schneeberger C, Huber JC, Wenzl R. Polymorphism in the IL-1 gene and endometriosis. J Soc Gynecol Invest 2003; 10: 172-175.

Wieser F, Fabjani G, Tempfer C, Schneeberger C, Sator M, Huber JC, Wenzl R. Analysis of an interleukin-6 gene promotor polymorphism in women with endometriosis by pyrosequencing. J Soc Gynecol Invest 2003; 10: 32-36.


Book Chapters


Ditzen B, Wieser F, Taylor RN. Endometriosis in the Encyclopedia of Behavioral Medicine. Springer Verlag 2011.

Wieser F, Taylor RN. Botanicals therapies in: Endometriosis current management and future trends. Garcia-Velasco JA, Botros RM RIZK B. Jaypee Brothers Medical Publishers (P) LTD 2010.

V Rötzscher (Hrsg.). Die komplizierte Anastomose; © J.A. Barth 1997. R Függer, M Imhof, F Wieser, P Götzinger, M Gnant, A Fritsch. Anastomosen bei Gallengangsstrikturen. Universitätsklinik für Chirurgie Wien.

Thesis


Wieser F: Etiologic factors in endometriosis. PD (Ph.D. equivalent) Thesis, Department of Gynecology and Obstetrics, Vienna University Medical School, Vienna, Austria 2004.


Selected Abstracts


59th Annual Meeting for the Society of Gynecological Investigation. Jillian M Liu, Angel A Rivera, Jasmine R Bryant, Michael Walden, Winston Thomas, Robert N Taylor, Neil Sidell, Friedrich Wieser. A nine-herb formulation, suppresses growth of endometriotic tissue implants in a mouse model of endometriosis. 2012. San Diego, CA.

67th Annual Meeting of the American Society of Reproductive Medicine. Retinoid acid suppresses lesion development, inhibits peritoneal cytokine secretion, and upregulates macrophage function in an immunocompetent mouse model of endometriosis. Wieser F, Wu J, Zhaoju S, Sidell N, Fertil Steril 2011; Orlando, Fl.

58th Annual Meeting forn the Society of genecological Investigation. Title: Differences between Macrophage Infiltration in Normal Endometrium versus Endometrioid Adenocarcinomas. Dun E, Bohman S, Makhija S, Wieser F, Taylor R.

58th Annual Meeting for the Society of genecological Investigation. Nabli H, Wieser F, Taylor RN, Sharpe-Timms KL. Differential expression of RANTES and MMP9 in endometrium from an established rat model of endometriosis: a link to endometriosis-related subfertility? Soc Gynecol Invest 2011, P F-197, Miami, FL.

2011 USCAP Annual Meeting. Tumor Associated Macrophages and Correlation with Prognostic Factors in Endometrial Adenocarcinomas Summer Bohman, Erica Dun, Evelyn Reynolds, Jie Yi, Fritz Wieser, Robert Taylor, and Krisztina Hanley. San Antonio, TX. February 26 −March 4, 2011.

66th Annual Meeting of the American Society of Reproductive Medicine. Retinoid acid suppresses growth of endometriotic implants in an immunocompetent mouse model of endometriosis. Wieser F, Zhaoju S, Sidell N, Fertil Steril 2010.

57th Annual Meeting for the Society of Gynecologic Investigation, March 2010, Orlando, FA. Xin Tan, Ph.D., Erica Dun, M.D., Dennis Liotta, Ph.D., Ira Horowitz, M.D., Robert N. Taylor, M.D., Ph.D., Fritz Wieser, M.D., P.D. EF24, A Novel Synthetic Curcumin Analog, Exhibits Anti-Tumor Activities in in vitro Human Ovarian Adenocarcinoma Cell Models Reproductive Sciences.

9th International Conference of the International Association of the Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (IACFS/ME). Boneva RS, Lin JS, Maloney EM, Wieser F, Jones J, Reeves WC. Gynecological history in women with CFS: a population-based study in Wichita, KS; at Reno, NV, March 12-15, 2009.

65th Annual Meeting Meeting of the American Society for Reproductive Medicine, Atlanta, GA October 17-21, 2009. P-72. Presence of chronic fatigue syndrome in endometriosis is associated with increased pshychological stress and reduced cortisol levels. Wieser, Boneva RS, Maloney E, Taylor RN, Reeves WWC, Nater UM. Fertil Steril 2009; 92: 3 S109.

42nd Annual SSR meeting, July 18-22, 2009, Phildadelphia, Pittsburgh. Effects of a Curcumin Analog, EF24, on Reproductive Function in Rats. Wieser F, Yu J, Sharpe-Timms K, Sidell N, Taylor RN. Biol Reprod 81: 641.

56th Annual Scientific Meeting of the Society of Gynecologic Investigation, March 2009, Glasgow, Scotland. Xin Tan, cand. Ph.D., Jie Yu, M.D., Alessandra Mancini, Ph.D., Robert N. Taylor M.D., Ph.D. Fritz Wieser, M.D., P.D. Curcumin and curcumin analogs suppress proliferation, angiogenesis and induce apoptosis in eutopic endometriotic cells.

54th Annual meeting of the ASRM October 2007. Wasghinton, USA. Wieser F, J. Yu, J. Park, N. Sidell, R. N. Taylor. Curcumin suppresses angiogenesis in an in vitro model of endometriosis.

55th Annual Scientific Meeting of the Society for Gynecologic Investigation, March, 2008, San Diego, USA. Tan X, Sidell N, Huang RP, Taylor RN, Wieser F. Curcumin suppresses angiogenesis, cell proliferation, and induced apoptosis in an in vitro model of endometriosis. Fertil Steril 2007;88, S204-S205 Fertil Steril 2007;88, S204-S205.

53rd Annual meeting of the ASRM October 2006, New Orleans, LA, USA. Wieser F, Park, J, Yu J, Murphy A, Sidell N, Taylor RN. Pro-oxidants induce cell proliferation and NF-KappaB in an immortalized endometrial epithelial cell line (EM-42).