Alicia Smith, PhD


Vice Chair


Associate Professor

Department of Gynecology and Obstetrics, Division of Research

Office: 101 Woodruff Circle, Suite 4217, Atlanta, GA 30322

Additional Contact Information

Additional Websites


Education and Training

Graduate Education: 
Wake Forest University, Molecular Genetics, PhD, 2005

Postgraduate Training:
Postdoctoral Fellowship in Genetic Epidemiology, Centers for Disease Control and Prevention, Chronic Viral Diseases Branch, 2005-2007
Postdoctoral Fellowship in Psychiatric Genetics, Emory University School of Medicine, Department of Human Genetics, 2007-2008

Previous Academic Appointments

Associate Professor, Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine

Areas of Interest

Dr. Smith’s primary research interest explores the genetic and epigenetic correlates of human behavior and psychopathology, particularly related to the role of prenatal and early life exposures on the development of stress-related disorders throughout the lifespan.

Awards and Honors

•  Distinguished Service Award, Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 2015
•  Travel Award, American College of Neuropsychopharmacology, 2013
•  Distinguished Scientific Contributions Award, Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 2013
•  NIH Pediatric Loan Repayment Program, 2011-2013
•  ADHD Molecular Genetics Network Travel Award, 2008
•  Riken Brain Science Institute Travel Award, 2008
•  Society of Biological Psychiatry Travel Award, 2008
•  Research Fellowship, Oak Ridge Institute for Science and Education, 2005
•  Travel Award for Graduate Students, North Carolina Biotechnology Center, 2004
•  Dean’s Fellowship, Wake Forest University School of Medicine, 2000

Society and Professional Memberships

•  American Society of Human Genetics
•  International Society of Psychiatric Genetics
•  Society of Biological Psychiatry
•  American College of Neuropsychopharmacology


Research Articles

Jovanovic T, Vance LA, Cross D, Knight AK, Kilaru V, Michopoulos V, Klengel T, Smith AK. Exposure to Violence Accelerates Epigenetic Aging in Children. Sci Rep. 2017 Aug 21;7(1):8962. Doi: 10.1038/s41598-017-09235-9. PMID: 28827677

Logue MW, Smith AK, Wolf EJ, Maniates H, Stone A, Schichman SA, McGlinchey RE, Milberg W, Miller MW. The correlation of methylation levels measured using Illumina 450K and EPIC BeadChips in blood samples. Epigenomics. 2017 Aug 15. doi: 10.2217/epi-2017-0078. [Epub ahead of print] PMID: 28809127

Mehta D, Bruenig D, Carrillo-Roa T, Lawford B, Harvey W, Morris CP, Smith AK, Binder EB, Young RM, Voisey J. Genomewide DNA methylation analysis in combat veterans reveals a novel locus for PTSD. Acta Psychiatr Scand. 2017 Aug 9. doi: 10.1111/acps.12778. [Epub ahead of print] PMID: 28795405

Park HJ, Bailey LB, Shade DC, Hausman DB, Hohos NM, Meagher RB, Kauwell GP, Lewis RD, Smith AK. Distinctions in gene-specific changes in DNA methylation in response to folic acid supplementation between women with normal weight and obesity. Obes Res Clin Pract. 2017 Jul 18. pii: S1871-403X(17)30062-5. doi: 10.1016/j.orcp.2017.06.004. [Epub ahead of print] PMID: 28733112

Ratanatharathorn A, Boks MP, Maihofer AX, Aiello AE, Amstadter AB, Ashley-Koch AE, Baker DG, Beckham JC, Bromet E, Dennis M, Garrett ME, Geuze E, Guffanti G, Hauser MA, Kilaru V, Kimbrel NA, Koenen KC, Kuan PF, Logue MW, Luft BJ, Miller MW, Mitchell C, Nugent NR, Ressler KJ, Rutten BPF, Stein MB, Vermetten E, Vinkers CH, Youssef NA; VA Mid-Atlantic MIRECC Workgroup; PGC PTSD Epigenetics Workgroup, Uddin M, Nievergelt CM, Smith AK. Epigenome-wide association of PTSD from heterogeneous cohorts with a common multi-site analysis pipeline. Am J Med Genet B Neuropsychiatr Genet. 2017 Jul 10. doi: 10.1002/ajmg.b.32568. [Epub ahead of print] PMID: 28691784

Smith AK, Jovanovic T, Kilaru V, Lori A, Gensler L, Lee SS, Norrholm SD, Massa N, Cuthbert B, Bradley B, Ressler KJ, Duncan E. A Gene-Based Analysis of Acoustic Startle Latency. Front Psychiatry. 2017 Jul 6;8.117. doi: 10.3389/fpsyt.2017.00117. eCollection 2017. PMID: 28729842

Sengupta SM, Smith AK, Grizenko N, Joober R. Locus-specific DNA methylation changes and phenotypic variability in children with attention-deficit hyperactivity disorder. Psychiatry Res. 2017 Jun 20;256:298-304. doi: 10.1016/j.psychres.2017.06.048. [Epub ahead of print] PMID: 28662467

Johnson ND, Wiener HW, Smith AK, Nishitani S, Absher DM, Arnett DK, Aslibekyan S, Conneely KN. Non-linear patterns in age-related DNA methylation may reflect CD4+ T cell differentiation. Epigenetics. 2017 Jun 3;12(6):492-503. doi: 10.1080/15592294.2017.1314419. Epub 2017 Apr 7. PMID: 28387568

Girchenko P, Lahti J, Czamara D, Knight AK, Jones MJ, Suarez A, Hämäläinen E, Kajantie E, Laivuori H, Villa PM, Reynolds RM, Kobor MS, Smith AK, Binder EB, Räikkönen K. Associations between maternal risk factors of adverse pregnancy and birth outcomes and the offspring epigenetic clock of gestational age at birth. Clin Epigenetics. 2017 May 8;9:49. doi: 10.1186/s13148-017-0349-z. eCollection 2017. PMID: 28503212

Kaushal A, Zhang H, Karmaus WJJ, Ray M, Torres MA, Smith AK, Wang SL. Comparison of different cell type correction methods for genome-scale epigenetics studies. BMC Bioinformatics. 2017 Apr 14;18(1):216. Doi: 10.1186/s12859-017-1611-2. PMID: 28410574

Knight AK, Conneely KN, Smith AK. Gestational age predicted by DNA methylation: potential clinical and research utility. Epigenomics. 2017 Jan 23. Doi: 10.2217/epi-2016-0157. [Epub ahead of print] PMID; 28111986

Maddox SA, Kilaru V, Shin J, Jovanovic T, Almli LM, Dias BG, Norrholm SD, Fani N, Michopoulos V, Ding Z, Conneely KN, Binder EB, Ressler KJ, Smith AK. Estrogen-dependent association of HDAC4 with fear in female mice and women with PTSD. Mol Psychiatry. 2017 Jan 17. Doi: 10.1038/mp.2016.250. [Epub ahead of print] PMID: 28093566

Ligthart S, Marzi C, Aslibekyan S, Mendelson MM, Conneely KN, Tanaka T, Colicino E, Waite LL, Joehanes R, Guan W, Brody JA, Elks C, Marioni R, Jhun MA, Agha G, Bressler J, Ward-Caviness CK, Chen BH, Huan T, Bakulski K, Salfati EL; WHI-EMPC Investigators., Fiorito G; CHARGE epigenetics of Coronary Heart Disease., Wahl S, Schramm K, Sha J, Hernandez DG, Just AC, Smith JA, Sotoodehnia N, Pilling LC, Pankow JS, Tsao PS, Liu C, Zhao W, Guarrera S, Michopoulos VJ, Smith AK, Peters MJ, Melzer D, Vokonas P, Fornage M, Prokisch H, Bis JC, Chu AY, Herder C, Grallert H, Yao C, Shah S, McRae AF, Lin H, Horvath S, Fallin D, Hofman A, Wareham NJ, Wiggins KL, Feinberg AP, Starr JM, Visscher PM, Murabito JM, Kardia SL, Absher DM, Binder EB, Singleton AB, Bandinelli S, Peters A, Waldenberger M, Matullo G, Schwartz JD, Demerath EW, Uitterlinden AG, van Meurs JB, Franco OH, Chen YI, Levy D, Turner ST, Deary IJ, Ressler KJ, Dupuis J, Ferrucci L, Ong KK, Assimes TL, Boerwinkle E, Koenig W, Arnett DK, Baccarelli AA, Benjamin EJ, Dehghan A. DNA methylation signatures of chronic low-grade inflammation are associated with complex diseases. Genome Biol. 2016 Dec 12;17(1):255. PMID: 27955697.

Mayne BT, Leemaqz SY, Smith AK, Breen J, Roberts CT, Bianco-Miotto T. Accelerated placental aging in early onset preeclampsia pregnancies identified by DNA methylation. Epigenomics. 2016 Nov 29. [Epub ahead of print] PMID: 27894195

Liu C, Marioni RE, Hedman ÅK, Pfeiffer L, Tsai PC, Reynolds LM, Just AC, Duan Q, Boer CG, Tanaka T, Elks CE, Aslibekyan S, Brody JA, Kühnel B, Herder C, Almli LM, Zhi D, Wang Y, Huan T, Yao C, Mendelson MM, Joehanes R, Liang L, Love SA, Guan W, Shah S, McRae AF, Kretschmer A, Prokisch H, Strauch K, Peters A, Visscher PM, Wray NR, Guo X, Wiggins KL, Smith AK, Binder EB, Ressler KJ, Irvin MR, Absher DM, Hernandez D, Ferrucci L, Bandinelli S, Lohman K, Ding J, Trevisi L, Gustafsson S, Sandling JH, Stolk L, Uitterlinden AG, Yet I, Castillo-Fernandez JE, Spector TD, Schwartz JD, Vokonas P, Lind L, Li Y, Fornage M, Arnett DK, Wareham NJ, Sotoodehnia N, Ong KK, van Meurs JB, Conneely KN, Baccarelli AA, Deary IJ, Bell JT, North KE, Liu Y, Waldenberger M, London SJ, Ingelsson E, Levy D. A DNA methylation biomarker of alcohol consumption. Mol Psychiatry. 2016 Nov 15. doi: 10.1038/mp/2016.192. [Epub ahead of print] PMID: 27843151

Clive ML, Boks MP, Vinkers CH, Osborne LM, Payne JL, Ressler KJ, Smith AK, Wilcox HC, Kaminsky Z. Discovery and replication of a peripheral tissue DNA methylation biosignature to augment a suicide prediction model. Clin Epigenetics. 2016 Nov 3;8:113. PMID: 27822318

Knight AK, Craig JM, Theda C, Bækvad-Hansen M, Bybjerg-Grauholm J, Hansen CS, Hollegaard MV, Hougaard DM, Mortensen PB, Weinsheimer SM, Werge TM, Brennan PA, Cubells JF, Newport DJ, Stowe ZN, Cheong JL, Dalach P, Doyle LW, Loke YJ, Baccarelli AA, Just AC, Wright RO, Téllez-Rojo MM, Svensson K, Trevisi L, Kennedy EM, Binder EB, Iurato S, Czamara D, Räikkönen K, Lahti JM, Pesonen AK, Kajantie E, Villa PM, Laivuori H, Hämäläinen E, Park HJ, Bailey LB, Parets SE, Kilaru V, Menon R, Horvath S, Bush NR, LeWinn KZ, Tylavsky FA, Conneely KN, Smith AK. An epigenetic clock for gestational age at birth based on blood methylation data. Genome Biol. 2016 Oct 7;17(1):206. PMID: 27717399

Joehanes R, Just AC, Marioni RE, Pilling LC, Reynolds LM, Mandaviya PR, Guan W, Xu T, Elks CE, Aslibekyan S, Moreno-Macias H, Smith JA, Brody JA, Dhingra R, Yousefi P, Pankow JS, Kunze S, Shah S, McRae AF, Lohman K, Sha J, Absher DM, Ferrucci L, Zhao W, Demerath EW, Bressler J, Grove ML, Huan T, Liu C, Mendelson MM, Yao C, Kiel DP, Peters A, Wang-Sattler R, Visscher PM, Wray NR, Starr JM, Ding J, Rodriguez CJ, Wareham NJ, Irvin MR, Zhi D, Barrdahl M, Vineis P, Ambatipudi S, Uitterlinden AG, Hofman A, Schwartz J, Colicino E, Hou L, Vokonas PS, Hernandez DG, Singleton AB, Bandinelli S, Turner ST, Ware EB, Smith AK, Klengel T, Binder EB, Psaty BM, Taylor KD, Gharib SA, Swenson BR, Liang L, DeMeo DL, O'Connor GT, Herceg Z, Ressler KJ, Conneely KN, Sotoodehnia N, Kardia SL, Melzer D, Baccarelli AA, van Meurs JB, Romieu I, Arnett DK, Ong KK, Liu Y, Waldenberger M, Deary IJ, Fornage M, Levy D, London SJ. Epigenetic Signatures of Cigarette Smoking. Circ Cardiovasc Genet. 2016 Sep 20. pii: CIRCGENETICS.116.001506. [Epub ahead of print] PMID: 27651444

van  Rooij SJ, Stevens JS, Ely TD, Fani N, Smith AK, Kerley KA, Lori A, Ressler KJ, Jovanovic T. Childhood Trauma and COMT Genotype Interact to Increase Hippocampal Activation in Resilient Individuals. Front Psychiatry. 2016 Sep 14;7:156. doi: 10.3389/fpsyt.2016.00156. eCollection 2016. PMID: 27683563

Haas BW, Filkowski MM, Cochran RN, Denison L, Ishak A, Nishitani S, Smith AK. Epigenetic Modification of OXT and Human Sociability. Proc Natl Acad Sci USA. 2016 Jul 5; 113(27): E3816-23. doi: 10.1073/pnas.1602809113. Epub 2016 Jun 20. PMID: 27325757

Kilaru V, Iyer SV, Almli, LM, Stevens JS, Lori A, Jovanovic T, Ely TD, Bradley B, Binder EB, Koen N, Stein DJ, Conneely KN, Wingo AP, Smith AK, Ressler KJ. Genome-wide gene-based analysis suggests an association between Neuroligin 1 (NLGN1) and Post-traumatic Stress Disorder, Translational Psychiatry. 2016 May 24;6.e820.doi: 10.1038/tp.2016.69. PMID: 27219346

Schechter JC, Brennan PA, Smith AK, Stowe ZN, Newport DJ, Johnson KC. Maternal Prenatal Psychological Distress and Preschool Cognitive Functioning: the Protective Role of Positive Parental Engagement. J Abnorm Child Psychol. 2016 May 6. [Epub ahead of print] PMID: 27150387

Sadeh N, Spielberg JM, Logue MW, Wolf EJ, Smith AK, Lusk J, Hayes JP, Sperbeck E, Milberg WP, McGlinchey RE, Salat DH, Carter WC, Stone A, Schichman SA, Humphries DE, Miller MW. SKA2 Methylation Predicts Reduced Cortical Thickness in Prefrontal Cortex. Mol Psychiatry. 2016 Mar; 21(3); 299. doi: 10.1038/mp.2016.10. PMID: 26887336

Sadeh N, Spielberg JM, Logue MW, Wolf EJ, Smith AK, Lusk J, Hayes JP, Sperbeck E, Milberg WP, McGlinchey RE, Salat DH, Carter WC, Stone A, Schichman SA, Humphries DE, Miller MW.  SKA2 Methylation is associated with Decreased Prefrontal Cortical Thickness and Greater PTSD Severity among Trauma-Exposed Veterans, Molecular Psychiatry, 2016 Mar;21(3):357-63. doi: 10.1038/mp.2015.134. Epub 2015 Sep 1. PMID: 26324104

Johnson KC, Smith AK, Stowe ZN, Newport DJ, Brennan PA.  Preschool outcomes following prenatal antidepressant exposure: Differences in language and behavior, but not cognitive function. Journal of Clinical Psychiatry, 2016 Feb;77(2):e176-82. doi: 10.4088/JCP.14m09348. PMID: 26930533

Smearman EL, Almli LA, Conneely KN, Brody GH, Sales JM, Bradley B, Ressler KJ, Smith AK. Oxytocin receptor genetic and epigenetic variation: association with child abuse and adult psychiatric symptoms. Child Development, 2016 Jan-Feb;87(1):122-34. doi: 10.1111/cdev.12493. PMID 26822448

Zannas AS, Arloth J, Carrillo-Roa T, Iurato S, Röh S, Ressler KJ, Nemeroff CB, Smith AK, Bradley B, Heim C, Menke A, Lange JF, Brückl T, Ising M, Wray NR, Erhardt A, Binder EB, Mehta D. Lifetime stress accelerates epigenetic aging in an urban, African American cohort: relevance of glucocorticoid signaling.  Genome Biology, 2015 Dec 17;16:266. doi: 10.1186/s13059-015-0828-5. PMID 26673150

Wingo AP, Almli LM, Stevens JJ, Bustamante AC, Uddin M, Lori A, Koen N, Stein DJ, Smith AK, Aiello A, Koenen K, Wildman D, Galea S, Bradley B, Binder EB, Gibson G, Ressler KJ.  DICER1 and microRNA regulation in trauma-related comorbid PTSD and depression, Nature Communications, 2015 Dec 3;6:10106. doi: 10.1038/ncomms10106. PMID 26632874

Peters MJ, Joehanes R, Pilling LC, Schurmann C, Conneely KN, Powell J, Reinmaa E, Sutphin GL, Zhernakova A, Schramm K, Wilson YA, Kobes S, Tukiainen T; NABEC/UKBEC Consortium, Ramos YF, Göring HH, Fornage M, Liu Y, Gharib SA, Stranger BE, De Jager PL, Aviv A, Levy D, Murabito JM, Munson PJ, Huan T, Hofman A, Uitterlinden AG, Rivadeneira F, van Rooij J, Stolk L, Broer L, Verbiest MM, Jhamai M, Arp P, Metspalu A, Tserel L, Milani L, Samani NJ, Peterson P, Kasela S, Codd V, Peters A, Ward-Caviness CK, Herder C, Waldenberger M, Roden M, Singmann P, Zeilinger S, Illig T, Homuth G, Grabe HJ, Völzke H, Steil L, Kocher T, Murray A, Melzer D, Yaghootkar H, Bandinelli S, Moses EK, Kent JW, Curran JE, Johnson MP, Williams-Blangero S, Westra HJ, McRae AF, Smith JA, Kardia SL, Hovatta I, Perola M, Ripatti S, Salomaa V, Henders AK, Martin NG, Smith AK, Mehta D, Binder EB, Nylocks KM, Kennedy EM, Klengel T, Ding J, Suchy-Dicey AM, Enquobahrie DA, Brody J, Rotter JI, Chen YD, Houwing-Duistermaat J, Kloppenburg M, Slagboom PE, Helmer Q, den Hollander W, Bean S, Raj T, Bakhshi N, Wang QP, Oyston LJ, Psaty BM, Tracy RP, Montgomery GW, Turner ST, Blangero J, Meulenbelt I, Ressler KJ, Yang J, Franke L, Kettunen J, Visscher PM, Neely GG, Korstanje R, Hanson RL, Prokisch H, Ferrucci L, Esko T, Teumer A, van Meurs JB, Johnson AD.  The transcriptional landscape of age in human peripheral blood.  Nature Communications 2015 Oct 22;6:8570. doi: 10.1038/ncomms9570. PMID 26490707

Guo X, Li Z, Zhang C, Yi Z, Li H, Cao L, Yuan C, Hong W, Wu Z, Peng D, Chen J, Xia W, Zhao G, Wang F, Yu S, Cui D, Xu Y, Golam CM, Smith AK, Wang T, Fang Y. Down-regulation of PRKCB1 expression in Han Chinese patients with subsyndromal symptomatic depression. J Psychiatr Res. 2015 Oct;69:1-6. PMID: 26343587

Kaminsky Z, Wilcox HC, Eaton WW, Van Eck K, Jovanovic T, Klengel T, Bradley B, Binder EB, Ressler KJ, Smith AK. Epigenetic and Genetic Variation at SKA2 Predict Suicidal Behavior and Post Traumatic Stress Disorder, Translational Psychiatry. 2015 Aug 25;5:e627. doi: 10.1038/tp.2015.105. PMID  26305478

Parets SE, Conneely KN, Kilaru V, Fortunato SJ, Syed TA, Saade G, Menon R, Smith AK. (2015). DNA Methylation provides insight into intergenerational risk for preterm birth in African Americans. Epigenetics. 2015;10(9):784-92. doi: 10.1080/15592294.2015.1062964. Epub 2015 Jun 19. PMID  26090903

Almli LM, Stevens JS, Smith AK, Kilaru V, Meng Q, Flory J, Abu-Amara D, Hammamieh R, Yang R, Mercer KB, Binder EB, Bradley B, Hamilton S, Jett M, Yehuda R, Marmar CR, Ressler KJ.  A genome-wide identified risk variant for PTSD is a methylation quantitative trait locus and confers decreased cortical activation to fearful faces.  American Journal of Medical Genetics Part B, Neuropsychiatric Genetics. 2015 Jul;168B(5):327-36. doi: 10.1002/ajmg.b.32315. PMID  25988933 

Haas BW, Smith AK. Oxytocin, vasopressin, and Williams syndrome: epigenetic effects on abnormal social behavior. Frontiers in Genetics, 2015 Feb 17;6:28. PMID  25741359  

Logue MW, Smith AK, Baldwin C, Wolf EJ, Guffanti G, Ratanatharathorn A, Stone A, Schichman SA, Humphries D, Binder EB, Arloth J, Menke A, Uddin M, Wildman D, Galea S, Aiello AE, Koenen KC, Miller MW. An analysis of gene expression in PTSD implicates genes involved in the glucocorticoid receptor pathway and neural responses to stress. Psychoneuroendocrinolgy, 2015 Mar 24;57:1-13. PMID  25867994

Mozhui K, Smith AK, Tylavsky FA. Ancestry dependent patterns in DNA methylation and influence of maternal nutrition. PLOS One, 2015 Mar 5;10(3):e0118466. PMID: 25742137

Behnia F, Parets SE, Kechichian T, Yin H, Dutta EH, Saade GR, Smith AK, Menon R.  Fetal DNA Methylation of Autism Spectrum Disorders (ASD) Candidate Genes: Association with Spontaneous Preterm Birth.  American Journal of Obstetrics & Gynecology, 2015 Apr;212(4):533.e1-9. PMID  25687563

Smith AK, Kilaru V, Klengel T, Arloth J, Mercer KB, Bradley B, Conneely KN, Ressler KJ, Binder EB.  DNA extracted from saliva for methylation studies of psychiatric traits: evidence for cross tissue environmental effects and relatedness to brain.  American Journal of Medical Genetics Part B, Neuropsychiatric Genetics, 2015 Jan;168B(1):36-44.

Smith AK, Conneely KN, TW Pace, Mister D, Felger JC, Kilaru V, Akel MJ, Vertino PM, Miller AH, Torres MA.  An Epigenetic Memory of Prior Chemotherapy Associated with Inflammation Related to Fatigue in Breast Cancer Patients. Brain, Behavior, and Immunity, 2014 May;38:227-236.

Smith AK, Kilaru V, Kocak M, Almli LM, Mercer KB, Ressler KJ, Tylavsky FA, Conneely KN. Methylation Quantitative Trait Loci (mQTLs) are Consistently Detected across Ancestry, Developmental Stage and Tissue Type. BMC Genomics, 2014 Feb 21;15:145.

Barfield RT, Almli LM, Kilaru V, Smith AK, Mercer KB, Duncan R, Klengel T, Mehta D, Binder EB, Epstein MP, Ressler KJ, Conneely KN.  Accounting for Population Stratification in DNA Methylation Studies. Genetic Epidemiology, 2014 Apr;38(3):231-241.

Sun YV, Smith AK, Conneely KN, Chang Q, Li W, Lazarus A, Smith JA, Binder EB, Klengel T, Cross D, Turner ST, Ressler KJ, Kardia SLR.  Epigenomic Association Analysis Identifies Smoking-related DNA Methylation Sites in African Americans. Human Genetics, 2013 Sep;132(9):1027-1037. 

Parets SE, Conneely KN, Kilaru V, Fortunato SJ, Syed TA, Saade G, Smith AK, Menon R. Fetal DNA Methylation Associates with Spontaneous Preterm Birth and Gestational Age. PLOS One, 2013 Jun 27;8(6):e67489.

Mehta D, Klengel T, Conneely KN, Smith AK, Rex-Haffner M, Loeschner A, Gonik M, Mercer KB, Bradley B, Müller-Myhsok B, Ressler KJ and Binder EB.  Evidence for distinct biological perturbations in PTSD with severe child abuse versus no child abuse: consequences for robust biomarkers for PTSD, Proceedings of the National Academy of Sciences, 2013 May 14;110(20):8302-8207.

Norrholm SD, Jovanovic T, Smith AK, Binder E, Klengel T, Conneely KN, Mercer KB, Davis JS, Kerley K, Winkler J, Gillespie CF, Bradley B, Ressler KJ.  Genetic and Epigenetic Regulation of Catechol-O-Methyl-Transferase (COMT) are Associated with Impaired Fear Inhibition in Posttraumatic Stress Disorder, Frontiers in Behavioral Neuroscience, 2013, Apr: 7(30):1-10.

Gillespie CF, Almli LM, Smith AK,  Bradley B,  Kerley K, Crain DF,  Mercer KB,  Weiss T,  Phifer J,  Tang YL,  Cubells JF,  Binder EB,  Conneely KN and  Ressler KJ.  Sex dependent influence of a functional polymorphism in steroid 5-α-reductase type 2 (SRD5A2) on post-traumatic stress symptoms. American Journal of Medical Genetics Part B Neuropsychiatric Genetics. 2013 Apr;162(3):283-292. 

Gordon L, Joo EJ, Powell JE, Ollikainen M, Novakovic B, Li S, Andronikos R, Cruickshank MN, Conneely KN, Smith AK, Alisch RS, Morley R, Visscher PM, Craig JM, Saffery R.  Neonatal DNA methylation profile in human twins is specified by a complex interplay between intrauterine environmental/ genetic factors subject to tissue-specific influence.  Genome Research, 2012 Aug;22(8):1395-1406.

Pei Y, Smith AK, Wang Y, Pan Y, Yang J, Chen Q, Pan W, Bao F, Zhao L, Tie D, Wang Y, Wang J, Zhen W, Zhou J, Ma X. The brain-derived neurotrophic-factor (BDNF) Val66Met polymorphism is associated with geriatric depression: A meta-analysis. American Journal of Medical Genetics Part B Neuropsychiatric Genetics 2012 Jul;159B(5):560-566.

Barfield RT, Kilaru V, Smith AK, Conneely KN. CpGassoc: an R function for analysis of DNA methylation microarray data.  Bioinformatics, 2012 May 1;28(9):1280-1281.

Smith AK, Conneely KN, Newport DJ, Kilaru V, Schroeder JW, Pennell PB, Knight BT, Cubells JC, Stowe ZN, Brennan PA. Prenatal Antiepileptic Exposure Associates with Changes in Neonatal DNA Methylation. Epigenetics. 2012 May 1;7(5).

Schroeder JW, Smith AK, Brennan PA, Conneely KN, Kilaru V, Knight BT, Newport DJ, Cubells JC, Stowe ZN. DNA Methylation of Neonates Born to Women Receiving Psychiatric Care. Epigenetics, 2012 Apr 1;7(4).

Kilaru V, Barfield RT, Schroeder JW, Smith AK, Conneely KN. MethLAB: A GUI Package for the Analysis of Array-Based DNA Methylation Data. Epigenetics, 2012 Mar;7(3):225-9.

Schroeder JW, Conneely KN, Cubells JC, Kilaru V, Newport DJ, Knight BT, Stowe ZN, Brennan PA, Krushkal J, Tylavsky FA, Taylor RN, Adkins RM, Smith AK.Neonatal DNA Methylation Patterns Associate with Gestational Age. Epigenetics, 2011 Dec; 6(12): 1498 – 1504.

Smith AK, Conneely KN, Kilaru V, Mercer KB, Weiss TE, Bradley-Davino B, Tang Y, Gillespie CF, Cubells JF, Ressler KJ (2011). Differential immune system DNA methylation and cytokine regulation in Posttraumatic Stress Disorder.  American Journal of Medical Genetics Part B, Neuropsychiatric Genetics 2011 Sep;156(6):700-708

Smith AK, Simon JS, Gustafson EL, Noviello S, Cubells JF, Epstein MP, Devlin DJ, Qiu P, Albrecht JK, Brass CA, Sulkowski MS, McHutchinson JG, Miller AH.  Association of a Polymorphism in the Indoleamine-2,3-Dioxygenase Gene and Interferon-α-Induced Depression in Patients with Chronic Hepatitis C. Molecular Psychiatry 2012 Jul;17(8):781-789.

Smith AK, Fang H, Whistler T, Unger ER, Rajeevan MS. Genomic Studies Identify Associations of GRIK2 and NPAS2 with Chronic Fatigue Syndrome. Neuropsychobiology. 2011;64(4):183-194.

Smith AK, Newport DJ, Ashe MP, Brennan PA, LaPrairie JL, Calamaras M, Nemeroff CB, Ritchie JC, Cubells JF, Stowe ZN. Predictors of Neonatal Hypothalamic-Pituitary-Adrenal Axis Activity at Delivery. Clinical Endocrinology 2011 Jul; 75(1):90-95.

Weiss T, Skelton K, Phifer J, Jovanovic T, Gillespie C, Smith AK, Umpierrez G, Bradley B, Ressler KJ. Posttraumatic Stress Disorder is a Risk Factor for Metabolic Syndrome in an Impoverished Urban Population. General Hospital Psychiatry. 2011 Mar-Apr;33(2):135-142.

Brennan PA, Hammen C, Sylvers P, Bor W, Najman J, Lind P, Montgomery G, Smith AK.  Interactions Between the COMT Val108/158Met Polymorphism and Maternal Prenatal Smoking Predict Aggressive Behavior Outcomes. Biological Psychology. 2011 Apr;87(1):99-105.

Ressler KJ, Mercer KB, Bekh Bradley B, Jovanovic T, Mahan A, Kerley K, Norrholm SD, Kilaru V, Smith AK, Myers A.J., Ramirez M, Engel A,  Hammack SE, Toufexis D, Braas KM, Binder EB and May V.  PTSD is associated with the PAC1 receptor and dysregulation of PACAP. Nature. 2011 Feb 24;470(7335):492-497.

Brand SR, Brennan PA, Newport DJ, Smith AK, Weiss TE, Stowe ZN.  The Impact of Maternal Childhood Abuse on Maternal and Infant HPA Axis Function in the Postpartum Period. Psychoneuroendocrinology. 2010 Jun;35(5):686-693.

Xiao L, Tang YL, Smith AK, Xiang YT, Sheng LX, Chi Y, Du WJ, Guo S, Jiang ZN, Zhang GF, & Luo XN.  A Nocturnal Sleep Architecture Disturbances in Early Methadone Treatment.  Psychiatry Research. 2010 Aug; 179(1):91-95.

Ressler KJ, Bradley B, Mercer KB, Deveau TC, Smith AK, Gillespie CF, Nemeroff CB, Cubells JF, Binder EB. Polymorphisms in CRHR1 and the serotonin transporter loci: gene x gene x environment interactions on depressive symptoms. American Journal of Medical Genetics Part B Neuropsychiatric Genetics. 2010 Apr 5;153B(3):812-824.

Binder EB, Newport DJ, Zach EB, Smith AK, Deveau TC Altshuler LL, Cohen LS, Stowe ZN, Cubells JF. A serotonin transporter gene polymorphism predicts peripartum depressive symptoms in an at risk psychiatric cohort. Journal of Psychiatric Research 2010 Jul;44(10):640-646.

Gillespie CF, Bradley B, Mercer K, Smith AK, Conneely K, Gapen M, Weiss T, Schwartz AC, Cubells JF & Ressler KJ. Trauma exposure and stress-related disorders in inner city primary care patients. General Hospital Psychiatry. 2009 Nov-Dec;31(6):505-514

Zhang GF, Tang YL, Smith AK, Liu ZQ, Sheng LX, Chi Y, Du WJ, Guo S, Jiang ZN, Xiao L, Zhang HX, & Luo XN.  Alterations in Pituitary-thyroid Axis Function among Opioid Dependent Subjects after Acute and Protracted Abstinence.  Addiction Biology 2009 Jul;14(3):310-314.

Smith AK, Maloney EM, Falkenberg VR, Dimulescu I, Rajeevan MS. An Angiotensin-1 Converting Enzyme Polymorphism is Associated with Allostatic Load Mediated by C-reactive protein, Interleukin-6 and Cortisol.  Psychoneuroendocrinology  2009 May;34(4):597-606.

Zhang G, Tang Y, Smith AK, Ren Y, Liu Z, Sheng L, Chi Y, Du W, Guo S, Jiang Z, Zhang H, Xiao L & Luo X. Dysfunction of the Hypothalamic-Pituitary-Adrenal Axis in Opioid Dependent Subjects: Effects of Acute and Protracted Abstinence. American Journal of Drug and Alcohol Abuse. 2008;34(6):760-768.

Smith AK, Lange LA, Ampleford EJ, Meyers DA, Bleecker ER, Howard TD. Association of polymorphisms in CASP10 and CASP8 with FEV/FVC and bronchial hyperresponsiveness in ethnically diverse asthmatics.  Clinical and Experimental Allergy. 2008 Nov;38(11):1738-1744

Smith AK, Dimulescu I, Narasimhan S, Unger ER, Heim C, Vernon SD, Rajeevan MS. Genetic Evaluation of the Serotonergic System in Chronic Fatigue Syndrome. Psychoneuroendocrinology. 2008 Feb; 33(2):188-197

Rajeevan MS, Smith AK, Dimulescu I, Vernon SD, Heim C, Reeves WC. Association of Polymorphisms and Haplotypes in the Glucocorticoid Receptor with Chronic Fatigue Syndrome.  Genes, Brain and Behavior 2007 Mar; 6(2):167-176.

Smith AK, White PD, Aslakson E, Vollmer-Conna U, Rajeevan MS. Polymorphisms in Genes Regulating HPA axis Associated with Empirically Delineated Classes of Unexplained Chronic Fatigue.  Pharmacogenomics 2006 Apr; 7(3): 387-394.

Howard TD, Postma DS, Hawkins GA, Koppelman GH, Zheng SL, Wysong AKS, Xu J, Meyers DA, Bleecker ER.  Fine mapping of an IgE-controlling gene on chromosome 2q: Analysis of CTLA4 and CD28. Journal of Allergy and Clinical Immunology. 2002 Nov; 110(5):743-751.

Review Articles

Knight AK, Smith AK, Epigenetic Biomarkers of Preterm Birth and Its Risk Factors. Genes (Basel). 2016 Apr 13;7(4). pii: E15. doi: 10.3390/genes7040015. Review. PMID: 27089367

Parets SE, Knight AK, Smith AK. Insights into genetic susceptibility in the etiology of spontaneous preterm birth. The Application of Clinical Genetics. 2015 Dec 14;8:283-90. doi: 10.2147/TACG.S58612. eCollection 2015. Review. PMID: 267115857

MW Logue, AB Amstadter, DG Baker, L Duncan, KC Koenen, I Liberzon, MW Miller, RA Morey, CM Nievergelt, KJ Ressler, AK Smith, JW Smoller, MB Stein, JA Sumner M Uddin. The Psychiatric Genomics Consortium Posttraumatic Stress Disorder Workgroup: Posttraumatic stress disorder enters the age of large-scale genomic collaboration. Neuropsychopharmacology, 2015 Sep; 40(10):2287-97. doi: 10.1038/npp.2015.118. EPub 2015 Apr 23. PMID: 25904361

Parets SE, Bedient C, Menon R, Smith AK. (2014) Preterm Birth:  Methylation to Mechanisms. Biology 2014, Aug 3(3), 498-513

LM Almli, N Fani, AK Smith, KJ Ressler. Genetic approaches to understanding posttraumatic stress disorder.  International Journal of Neuropsychopharmacology, 2014 Feb;17(2):355-370.

JOE Enaw and AK Smith. Biomarker Development for Brain-based Disorders: Recent progress in Psychiatry. Journal of Neurology and Psychology, 2013 Nov 1;1(2):7.

Menon R, Conneely KN, Smith AK. DNA Methylation: An Epigenetic Risk Factor Understudied in Preterm Birth. Journal of Reproductive Sciences, Jan 2012 19(1) 6-13.

Smith AK, Mick E, Faraone SV. Advances in Genetic Studies of Attention-Deficit/Hyperactivity Disorder.  Current Psychiatry Reports. 2009 Apr;11(2):143-148.

Book Chapters

Smith AK and Meyers DA.  Family studies and positional cloning of genes for asthma and related phenotypes. Immunology and Allergy Clinics of North America. 2005 Nov;25(4):641-654.

Smith AK and JW Schroeder.  Epigenetics. In MD Gellman and JR Turner (Eds.) Encyclopedia of Behavioral Medicine, New York: Springer Reference, 2013 edition, December 31, 2012.

AK Smith, SE Parets, A Kim. Epigenetics of Psychopathology. In SH Rhee and A Ronald (Eds), Genetics of Psychopathology, Volume 5, New York: Springer Publishing, 2014.